Recently in Medication Safety – 24/02/15

Recently in Medication Safety – 24/02/15

Multiple Antihypertensives and Mortality in Nursing Home Residents

  • Benetos A, Labat C, Rossignol P, et al. Treatment with multiple blood pressure medications, achieved blood pressure, and mortality in older nursing home residents: The PARTAGE study. JAMA Intern Med 2015; DOI:10.1001/JAMAINTERNMED.2014.8012. Abstract

Long-Acting Opiods and Unintentional Overdoses

  • Miller M, Barber CW, Leatherman S, et al. Prescription Opioid Duration of Action and the Risk of Unintentional Overdose Among Patients Receiving Opioid Therapy. JAMA Intern Med. Published online February 16, 2015. doi:10.1001/jamainternmed.2014.8071 :

Risks of CYP3A4 Interactions of Statins in Older Adults

  • Daniel Q. Li, BSc, Richard Kim, MD, Eric McArthur, MSc, Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4, CMAJ February 17, 2015vol. 187 no. 3 174-180 :

Meta-Analysis of Epidemiological trials on Hormone Therapy and Ovarian Cancer Risk

NSAIDs Up Bleeding/CV Risks in Post-MI Patients Treated With Antithrombotic

  • Olsen AM, Gisalason GH, McGettigan P, et al. Association of NSAID use with risk of bleeding and cardiovascular events in patients receiving antithrombotic therapy after myocardial infarction. JAMA 2015; 313:805-814.

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